Confocal images of mouse brains associated with the publication: Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder

[ DOI: https://doi.org/10.35077/g.1169 ]

 

Dataset Citation:

Gradinaru, Viviana, Gradinaru Lab. (2024). Confocal images of mouse brains associated with the publication: Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder. [ Collection / Dataset ]. Brain Image Library. https://doi.org/10.35077/g.1169

 

Abstract:

Images of mouse brains, either expressing LRP6 or not, following systemic injection of AAVs to determine whether the AAVs use LRP6 to cross the blood-brain barrier. Data associated with Shay et al. (2024) "Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder." Nature Communications.

 

Funding:

National Institutes of Health 1-DP1-NS111369-01 Circuit-Specific Delivery of Large Cargo Across the Nervous Systems of Adult Mammals and Embryos via Novel Engineered Systemic Vectors;
National Institutes of Health 1-UF1-MH128336-01   Engineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across Species

 

Contributors:

Gradinaru, Viviana (ProjectLeader) [ORCID: https://orcid.org/0000-0001-5868-348X ] California Institute of Technology
Gradinaru Lab (ResearchGroup) California Institute of Technology

 

Related Identifiers:

IsCitedBy [ DOI : https://doi.org/10.1038/s41467-024-52149-0 ];
Requires [ URL : https://download.brainimagelibrary.org/84/a6/84a6b0a693ed977b/ ];
Requires [ URL : https://download.brainimagelibrary.org/69/da/69da8a72dcdf45d0/ ];