A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease

[ DOI: https://doi.org/10.35077/g.1209 ]

 

Dataset Citation:

Fushiki, Akira. (2026). A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease. [ Collection / Dataset ]. Brain Image Library. https://doi.org/10.35077/g.1209

 

Abstract:

This dataset comprises a series of experiments corresponding to the imaging data described in the associated publication (PMID: 39763754). Animals were transcardially perfused with paraformaldehyde (PFA), and brain tissues were subsequently collected and processed for histological analysis according to the protocol detailed in the paper. Coronal brain sections were prepared from all animals included in the study and imaged using fluorescence microscopy. These sections were obtained to assess recombinase-dependent reporter expression as well as viral-mediated transgene expression.

 

Methods:

A detailed protocol for this work is available in the associated publication (PMID: 39763754) and on protocols.io (https://www.protocols.io/view/histology-fushiki-et-al-2024-5qpvo9o49v4o/v1).

 

Funding:

Aligning Science Across Parkinson's ASAP-020551 Distributed circuit dysfunction underlying motor and sleep deficits in a progressive mouse model of Parkinson’s disease

 

Contributors:

Fushiki, Akira (DataCollector) [ORCID: https://orcid.org/0000-0002-7987-6405 ] Allen Institute

 

Related Identifiers:

IsCitedBy [ DOI : https://doi.org/10.1101/2024.12.20.629776 ];
IsDocumentedBy [ DOI : https://doi.org/10.17504/protocols.io.5qpvo9o49v4o/v1 ];
Requires [ URL : https://download.brainimagelibrary.org/07/de/07dee2688f28595c/ ];