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Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum

[ DOI: https://doi.org/10.35077/g.1210 ]

Dataset Citation:

Liu, Xiao-Ping, Dalley, Rachel , Lee, Brian R., Kalmbach, Brian. (2026). Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum. [ Collection / Dataset ]. Brain Image Library. https://doi.org/10.35077/g.1210

Abstract:

The basal ganglia are evolutionary ancient subcortical nuclei that form interconnected loops with the neocortex and limbic system to regulate movement, learning, habit formation, emotion, and motivation. Their dysfunction contributes to major neurological and psychiatric disorders, yet most cellular-level insights derive from rodent studies, leaving knowledge gaps in humans and translationally relevant primate species. To address this, we generated multi-modal Patch-seq data linking transcriptomic identity with morphological and electrophysiological properties in macaque striatum, the input nucleus of the basal ganglia. We found underappreciated diversity among medium spiny neurons, including non-canonical types, and variation aligned with functional gradients. Interneurons also exhibited spatial variation and even greater morphoelectric diversity, highlighting their functional modularity. Despite broad evolutionary conservation, we identified primate-specific features and key differences from rodent striatal neurons. By integrating molecular classification with cellular properties that shape network function, our findings provide insights into the functional organization of the primate striatum.

TechnicalInfo:

Submission 08144a6de83c1d31 contains the SWC files and all other submissions contain the image stacks.

Funding:

National Institutes of Health 1-UM1-MH130981-01 Functionally guided adult whole brain cell atlas in human and NHP

Contributors:

Liu, Xiao-Ping (ProjectMember) [ORCID: https://orcid.org/0000-0003-3449-7601 ] Allen Institute for Brain Science
Dalley, Rachel (ProjectMember) [ORCID: https://orcid.org/0000-0001-7461-7845 ] Allen Institute for Brain Science
Lee, Brian R. (ProjectMember) [ORCID: https://orcid.org/0000-0002-3210-5638 ] Allen Institute for Brain Science
Kalmbach, Brian (ProjectMember) [ORCID: https://orcid.org/0000-0003-3136-8097 ] Allen Institute for Brain Science

Related Identifiers:

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