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BIL Logo Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

[ DOI: https://doi.org/10.35077/g.606 ]

 

Dataset Citation:
Chartrand, Thomas, Dalley, Rachel, Kalmbach, Brian, Tamas, Gabor, Mansvelder, Huibert D, Lein, Ed, Allen Institute For Brain Science. (2023). Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex. [ Collection / Dataset ]. Brain Image Library. https://doi.org/10.35077/g.606

 

Abstract:
Neocortical layer 1 (L1) is a site of convergence between pyramidal neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neuron types with extensive branching in L1, but whether L1 interneurons are similarly diverse is underexplored. Using patch-seq recordings from human neurosurgically resected tissues, we identified four transcriptomically defined subclasses, unique subtypes within those subclasses and additional types with no mouse L1 homologue. Compared with mouse, human subclasses were more strongly distinct from each other across all modalities. Accompanied by higher neuron density and more variable cell sizes compared with mouse, these findings suggest L1 is an evolutionary hotspot, reflecting the increasing demands of regulating the expanding human neocortical circuit.

 

Methods:
Experimental protocols are available on protocols.io via the links listed below. Detailed descriptions of experiemntal data collection methods are also available at help.brain-map.org/display/celltypes/Documentation. Human Neurosurgical Tissue Processing: dx.doi.org/10.17504/protocols.io.bf66jrhe Patch-Seq Internal Solution with Biocytin: dx.doi.org/10.17504/protocols.io.261geo4qol47/v4 Patch-Seq Recording and Extraction: dx.doi.org/10.17504/protocols.io.bw6gphbw Post Patch Clamp Slice Fixation: dx.doi.org/10.17504/protocols.io.bg5tjy6n DAB Detection of Biocytin Labeled Tissue: dx.doi.org/10.17504/protocols.io.bg5yjy7w 20X Anatomic and Layer Identification for Biocytin Filled Cells: dx.doi.org/10.17504/protocols.io.bey9jfz6, 3D Reconstruction of Neurons in Vaa3D: dx.doi.org/10.17504/protocols.io.36wgq5683gk5/v3

 

Funding:
National Institutes of Health None None

 

Contributors:
Chartrand, Thomas (ProjectMember) Allen Institute for Brain Science
Dalley, Rachel (ProjectMember) Allen Institute for Brain Science
Kalmbach, Brian (ProjectMember) Allen Institute for Brain Science
Tamas, Gabor (ProjectLeader) University of Szeged
Mansvelder, Huibert D (ProjectLeader) Vrije Universiteit Amsterdam
Lein, Ed (ProjectLeader) Allen Institute for Brain Science
Allen Institute For Brain Science (ResearchGroup) Allen Institute for Brain Science

 

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